张宏 教授

   研究领域：中药抗肿瘤药理

研究方向：成分中药的发现及配伍机制；创新中药研究开发

招生专业：生物与医药；植物学；临床中药学

联系方式：E-mail：zhanghong@chnu.edu.cn

张宏，男，四川成都人，博士，教授，博士生/硕士生导师。世界中医药联合会道地药材多维评价专业委员会常务理事，Current Pharmaceutical Design编委。连续三年（2023-2025）同时入选全球前2%顶尖科学家榜单和爱思唯尔中国高被引学者榜单。

长期从事中药复方药理研究，首次提出成分中药的概念及研究策略（中国科学:生命科学，2024），提出的“如何阐明方剂君臣佐使配伍机制的科学内涵”入选2023年国家中医药重大科学问题，并多次受邀在国际及全国性学术会议作大会报告。先后主持国家科技部重点研发计划、国家自然科学基金等纵向课题16项；获得中药新药临床批件1项，开发中药院内制剂5个；编写专著和教材10部，其中副主编4部，编委6部；授权发明专利11项；发表论文160余篇，其中以第一或通讯作者在Materials Today Bio、Cell Death Dis、Phytomedicine等杂志发表SCI论文92篇，在中国科学:生命科学、中国中药杂志、中华中医药杂志等核心期刊发表论文38篇，总引用9000余次，H指数50。

近五年代表性论文（第一或通讯作者）：

[1] Pei-Pei Wang, Cheng-Xun He, Yang-Yang Shuai, Jia-Xuan Wang, Hui Ao, Wei Peng*, Hong Zhang*. Macrophage membrane coating enhances the therapeutic effects of Houttuynia cordata exosome-like nanovesicles against triple-negative breast cancer. Materials Today Bio, 2025, 35: 102604.

[2] Pei-Pei Wang, Cheng-Xun He, Yang-Yang Shuai, Hai-Jun Zhang, Lei Zhang, Hui Ao*, Wei Peng*, Hong Zhang*. The combination of natural products: A promising therapeutical way for management of breast cancers. Phytotherapy Research, 2025, 39(9): 3886-3902.

[3] Zhi-Hui Feng, Wen-Yue Li, Qi-Zhang Li, Feng-Bo Zhao, Hai-Jun Zhang, Lei Zhang*, Hong Zhang*. Tylophora yunnanensis extract inhibits cholesterol biosynthesis to suppress triple negative breast cancer. Journal of Ethnopharmacology, 2025, 348: 119877.

[4] Qi-Zhang Li, Yu-Ying Chen, Qiu-Ping Liu, Zhi-Hui Feng, Lei Zhang*, Hong Zhang*. Cucurbitacin B suppresses hepatocellular carcinoma progression through inducing DNA damage-dependent cell cycle arrest. Phytomedicine, 2024, 126: 155177. 

[5] Yi-Qing Deng, Min Gao, Dong Lu, Qiu-Ping Liu, Run-Jing Zhang, Ji Ye, Jing Zhao, Zhi-Hui Feng, Qi-Zhang Li*, Hong Zhang*. Compound-composed Chinese medicine of Huachansu triggers apoptosis of gastric cancer cells through increase of reactive oxygen species levels and suppression of proteasome activities. Phytomedicine, 2024, 123:155169

[6] 张宏*，李奇璋，刘爱芬，曾克武，丁显廷，王博谦，史建伍，王成牛，辛海量，张磊*. 基于成分配伍的中药复方研究策略. 中国科学:生命科学，2024，54（5）：911-924.

[7] Qiu-Ping Liu, Yu-Ying Chen, Pei An, Khalid Rahman, Xin Luan*, Hong Zhang*. Natural products targeting macrophages in tumor microenvironment are a source of potential antitumor agents. Phytomedicine, 2023, 109: 154612. 

[8] Pei An, Dong Lu, Lijun Zhang, Haiyue Lan, Hongxuan Yang, Guangbo Ge, Wei Liu, Weixing Shen, Xianting Ding, Dongxin Tang, Weidong Zhang, Xin Luan*, Haibo Cheng*, Hong Zhang*. Synergistic antitumor effects of compound-composed optimal formula from Aidi injection on hepatocellular carcinoma and colorectal cancer. Phytomedicine, 2022, 103:154231.

[9] Yu-Ying Chen, Qiu-Ping Liu, Pei An, Min Jia, Xin Luan*, Jian-Yuan Tang*, Hong Zhang*. Ginsenoside Rd: A promising natural neuroprotective agent. Phytomedicine, 2022, 95:153883. 

[10] Pei An, Li-Jun Zhang, Wei Peng, Yu-Ying Chen, Qiu-Ping Liu, Xin Luan*, Hong Zhang*. Natural products are an important source for proteasome regulating agents. Phytomedicine, 2021, 93:153799.